Surface Modification Technology Platform

Endexo

Endexo Logo

Low molecular weight additives that provide passive surface modification of medical devices

Endexo® surface modifying macromolecules enhance the biocompatibility of medical devices that come in contact with blood, tissue, or other biological fluids. They are low molecular weight fluoro-oligomeric additives that migrate to the top few nanometers of the device surface during the manufacturing process.

In the presence of blood, the modified surfaces are able to suppress procoagulant protein conformation, reduce platelet adhesion and inhibit platelet activation. In the presence of bacteria mediated fluids the modified surfaces are effective at reducing bacteria adhesion (up to 5 log CFU) and encrustation. Endexo® modified devices reduce thrombosis, infection and biofouling all without the use of drugs.

Endexo® platform technology can be applied to a variety of base polymers (e.g. polyurethane, polysulfone, PVC, polypropylene, and silicone) and manufacturing techniques (e.g. extrusion, solution spinning, and injection molding). Endexo® molecules become an integral part of the base material providing durable surface modification and extended efficacy compared to traditional coatings.

ADVANTAGES

DEVICE
  • Passive surface modification
  • Permanent presence on all device surfaces
  • No impact on device functionality
MANUFACTURING
  • No change to existing manufacturing processes
  • Compatible with a wide range of base polymers
  • Low cost technology

angiodynamics logo

Licensed product 

fresiums logo

Licensed product 

Arkis logo

Licensed product 

COMMERCIAL APPLICATION CASE STUDY:

BIOFLO™ WITH ENDEXO (Marketed by ANGIODYNAMICS)

CLINICAL DATA

Average reduction across 8500 BioFlo PICCs studied:
As reported by AngioDynamics

Clinical Data

endexo case study

SOURCE: ANGO FDA Approval documents;
Needham & Company 14th Annual Healthcare Conference, April 14,2015

Play Video

BioFlo PICC Patient Story

Learn how the BioFlo PICC with Endexo technology offered a solution to this patient's PICC line infections

FUTURE OPPORTUNITIES

Blood Contacting Devices

Non-dialysis blood lines

Short-term catheters

Perfusion

Apheresis

Medical Device Anti-fouling

Urinary catheters and stents

Drainage devices

Sensors and diagnostics

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